By Mara Dierssen,Rafael de la Torre Fornell
Down syndrome (DS) is the most typical instance of neurogenetic aneuploid disease resulting in psychological retardation. generally, DS effects from an additional reproduction of chromosome 21 (HSA21) generating deregulated gene expression in mind that offers elevate to subnormal highbrow functioning. the subject of this quantity is of wide curiosity for the neuroscience neighborhood, since it tackles the concept that of neurogenomics, that's, how the genome as an entire contributes to a neurodevelopmental cognitive issues, reminiscent of DS, and therefore to the improvement, constitution and serve as of the frightened procedure.
This quantity of growth in mind study discusses comparative genomics, gene expression atlases of the mind, community genetics, engineered mouse types and purposes to human and mouse behavioral and cognitive phenotypes. It brings jointly scientists of numerous backgrounds, by way of facilitating the combination of analysis directed at diverse degrees of organic association, and through highlighting translational learn and the appliance of the prevailing medical wisdom to boost superior DS remedies and cures.
- Leading authors overview the state of the art of their box of research and supply their perspectives and views for destiny research
- Chapters are largely referenced to supply readers with a complete checklist of assets at the issues covered
- All chapters comprise entire historical past info and are written in a transparent shape that also is obtainable to the non-specialist
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Down Syndrome: From Understanding the Neurobiology to Therapy (Progress in Brain Research) by Mara Dierssen,Rafael de la Torre Fornell