By Gert Lubec
A new promising animal version of DS is stated and this opens new possibilities to review pathomechanisms and pharmacological techniques because it is greater than tough to hold out experiences in people and the scientific positive aspects are hugely variable. by way of biology, telephone cycle and stem mobilephone stories and when it comes to biochemistry, relevance of experiences on a selected protein kinase, channels, transporters, superoxide dismutase, antioxidant approach, chromosome meeting issue and different vital organic buildings are supplied. And back, the gene dosage speculation is addressed and even though nearly all of chromosome 21 gene items is unchanged in fetal DS mind, a number of particular chromosome 21 encoded constructions together with transcription elements are certainly overexpressed even supposing findings in fetal DS are diversified from these in grownup DS mind whilst Alzheimer-like neuropathology supervenes.
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Advances in Down Syndrome Research (Journal of Neural Transmission. Supplementa) by Gert Lubec