Download Absorption and Drug Development: Solubility, Permeability, by Alex Avdeef PDF

By Alex Avdeef

Explains how one can practice and examine the result of the most recent physicochemical methods

With this e-book as their advisor, readers have entry to the entire present info had to completely examine and thoroughly be certain a compound's pharmaceutical homes and their results on drug absorption. The booklet emphasizes oral absorption, explaining all of the physicochemical equipment used this day to investigate drug applicants. furthermore, the writer offers specialist counsel to assist readers research the result of their reviews so one can choose the main promising drug candidates.

This Second Edition has been completely up-to-date and revised, incorporating all of the most up-to-date learn findings, equipment, and assets, including:

  • Descriptions and functions of recent PAMPA types, drawing on greater than thirty papers released through the author's learn group

  • Two new chapters reading permeability and Caco-2/MDCK and permeability and the blood-brain barrier

  • Expanded details and strategies to help pKa determination

  • New examples explaining the remedy of essentially insoluble attempt compounds

  • Additional case experiences demonstrating using the newest physicochemical techniques

  • New, revised, and accelerated database tables in the course of the book

Well over 2 hundred drawings support readers higher comprehend tricky suggestions and supply a visible advisor to complicated strategies. moreover, over 800 references function a gateway to the first literature within the box, facilitating additional examine into the entire subject matters lined within the book.

This Second Edition is suggested as a reference for researchers in pharmaceutical R&D in addition to in agrochemical, environmental, and different similar parts of analysis. it's also steered as a supplemental textual content for graduate classes in pharmaceutics.

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Absorption and Drug Development: Solubility, Permeability, and Charge State by Alex Avdeef

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